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Carrie Perlman

Dr. Perlman’s laboratory studies lung mechanics in the context of acute lung injury. One of the hallmarks of acute lung injury is pulmonary edema, where liquid leaks out of the blood vessels into the airspace of the lung. This liquid-filling of the airspace causes patients to have difficulty breathing.

For breathing assistance, patients with acute lung injury are treated with mechanical ventilation. In providing sufficient gas exchange, however, mechanical ventilation can cause over-distension injury of the lungs and prevent recovery. The mortality rate is about 30% and patients often die from the ventilator injury, not the underlying lung disease.

To address this problem, her research analyzes the inflation mechanics of the edematous lung. The goal is to use her understanding of mechanics to inform development of novel treatment methods that reduce ventilator induced lung injury.

Research Images:
Selected Publications:
Wu Y, Perlman CE. (2012). In situ methods for assessing alveolar mechanics, Journal of Applied Physiology, 112 (3), 519-526
Perlman CE, Mockros LF. (2012). Predicted oxygenation efficacy of a thoracic artificial lung, ASAIO Jounral, 58 (3), 247-254
Perlman CE, Lederer DJ, Bhattacharya J. (2010). The micromechanics of alveolar edema, American Journal of Respiratory Cell and Molecular Biology, 44 (1), 34-49
Bhattacharya J, Perlman CE. (2010). Commentaries on Viewpoint: Standards for quantitative assessment of lung structure. Air space connectivity, Journal of Applied Physiology, 109 (3), 935-936
Kuo AS, Perlman CE, Mockros LF, Cook KE. (2008). Pulmonic valve function during thoracic artificial lung attachment, ASAIO Journal, (54), 197
Contact Information:

Carrie Perlman
cperlman@stevens.edu
Phone: 201.216.8779
McLean Hall
Castle Point on Hudson
Hoboken NJ 07030

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