Professor Abeywickrama researches the “Design, Synthesis and Evaluation of Biological Active Molecules”.
She is involved in both Synthetic Organic Chemistry and Bioactive Compound research focuses within the Department of Chemistry, Chemical Biology and Biomedical Engineering.
Her groups focus is on synthesizing novel heterocyclic molecules as new therapeutic approaches for cancer and infectious diseases. Dr. Abeywickrama plans to develop new compounds that can induce cell differentiation and could act as potential anti-cancer agents. Molecular modeling studies and bioassays will be used to design and characterize the most potent inhibitors.
Abeywickrama, C.; Matsuda, H .; Jockusch, S.; Zhou, J.; Jang, Y. P.; Chen, Bi-X.; Itagaki, Y.; Turro, N. J.; Erlanger. (2007). Immunochemical Recognition of A2E, a Pigment in the Lipofuscin of Retinal Pigment Epithelial Cells, Proceedings of the National Academy of sciences, USA, 104, 14610-14615
Abeywickrama, C.; Rotenberg, S. A; Baker, A. D. (2006). Inhibition of Protein Kinase C by Dequalinium Analogues: Structure-Activity Studies on Head Group Variations, Bioorganic & Medicinal Chemistry, 14, 7796-7803
Abeywickrama, C.; Baker, A. D. (2004). Efficient Synthesis of 1,4,5,12-Tetraazatriphenylene and Derivatives, Journal of Organic Chemistry, 69, 7741